While there’s never an ideal time for a cold sore to pop up, there are certain times in life when the presence of a fresh cold sore on your lip may make you want to lock yourself in your bedroom and cry:

10 of the Worst Times to Get a Cold Sore

  • The day of a flight
  • The first day of class
  • The day of a first date
  • The day of a job interview
  • The day of a major presentation
  • The day of a television appearance
  • The day of a parent-teacher conference
  • The day of your child’s big game / recital
  • Your birthday
  • Your wedding day

What to Do in the Event of a Cold Sore Emergency

Before a cold sore emergency strikes, it’s important to know your options and act swiftly. You may want to consult your physician now to obtain a proper diagnosis and recommended treatment plan. Depending on your situation, your physician may recommend an over-the-counter cold sore treatment that you can purchase at a local drug store.

Alternatively, your physician may recommend a prescription cold sore treatment, such as Sitavig® (acyclovir), 50mg Muco-Adhesive Buccal Tablet. Sitavig is an FDA-approved, single-dose prescription cold sore treatment that can ease cold sore symptoms, speed up healing, and in some cases, stop cold sores before they start.1

If you’ve got an important event coming up and you feel like you may get a cold sore, find a Sitavig prescribing physician near you to find out if prescription Sitavig can help.


1 – Bieber T, et al. Efficacy and Safety of Acyclovir Mucoadhesive Buccal Tablet in Immunocompetent Patients With Labial Herpes (LIP Trial): A Double-Blind, Placebo-Controlled, Self-Initiated Trial. J Drugs Dermatol. 2014;13(7):791-798. View study (link will lead you to the JDD site).


Sitavig should not be used in patients with known hypersensitivity to acyclovir, milk protein concentrate, or other components of the product.

Sitavig has not been studied in pregnant women or in immunocompromised patients and no interaction studies have been performed. Sitavig’s safety and efficacy have not been established in pediatric patients.

Sitavig is a Pregnancy Category B product; therefore it should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus. It is not known if Sitavig is excreted in breast milk; however, systemic absorption is minimal.

In a controlled clinical trial Sitavig’s most common side effects (greater than or equal to 1%) were: headache (3%), dizziness (1%), lethargy (1%), gingival pain (1%), aphthous stomatitis (1%), application site pain (1%), application site irritation (1%), erythema (1%) and rash (1%). In the same trial these side effects ranged from 0%-3% for placebo.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch.com or call 1-800-FDA-1088.

View Full Prescribing Information.